For research purposes only. This guide describes the chemical identity and laboratory handling of PT-141 and summarises findings reported in published research. It is not medical advice and does not describe any effect, dose, or use in humans or animals.
What is PT-141?
PT-141 (Bremelanotide) is a synthetic cyclic heptapeptide and a ligand of the melanocortin receptor family. Its sequence is Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH. It is supplied as a lyophilised powder for laboratory research.
PurePeptides offers PT-141 at >99% purity strictly for in-vitro research use. This page describes its chemical identity and handling only, and must not be interpreted as describing any effect in humans or animals.
PT-141, also known as Bremelanotide, is a synthetic cyclic heptapeptide and a ligand of the melanocortin receptor family. Its cyclic structure (Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH) places it among the melanocortin peptides. It is studied in research relating to melanocortin-receptor signalling. PurePeptides supplies it strictly as a research material; this page describes chemical identity and laboratory handling only and makes no claim about any effect in humans or animals.
Chemical identity & specifications
| Product | PT-141 |
| Full name | Bremelanotide |
| Synonyms | PT-141; Bremelanotide |
| Classification | Synthetic cyclic heptapeptide (melanocortin receptor ligand) |
| Sequence | Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH |
| Molecular weight | ~1025.2 g/mol |
| CAS number | 189691-06-3 |
| Solubility | Water-soluble |
| Purity | >99% |
| Physical form | Lyophilised powder |
| Storage | -20°C lyophilised; 2-8°C reconstituted |
| Intended use | Research use only - not for human consumption |
Handling PT-141 in research protocols
In laboratory settings, lyophilised PT-141 is typically stored at -20°C, protected from light and moisture, until use. For reconstitution, bacteriostatic water is a commonly cited solvent; once in solution, the material is generally kept refrigerated at 2-8°C with freeze-thaw cycles minimised to preserve peptide integrity.
Researchers quantify PT-141 by concentration within their experimental system — for example molar concentrations for in-vitro work, or amount-per-mass figures in animal models. These are parameters defined by the study design and reported in the literature; they are not dosing guidance for any human or animal use. To convert between vial mass, solvent volume, and target concentration for laboratory preparation, our peptide reconstitution calculator may be useful.
Findings reported in the research literature
PT-141 / Bremelanotide appears in melanocortin-receptor research literature. As a cyclic peptide ligand of this receptor family, it is referenced in in-vitro and preclinical receptor-pharmacology studies. The findings reported in that literature are experimental observations and are not statements about human use.
Any effects described in this literature are observations made in controlled experimental systems — cell assays and animal models — and are reported here only to summarise the scientific record. They do not constitute claims about outcomes, efficacy, benefits, or safety in humans, and nothing on this page should be read as encouraging human or animal use. Readers interested in the primary research can review the indexed literature via PubMed’s Bremelanotide results.
PT-141 in the melanocortin peptide family
PT-141 belongs to the melanocortin-receptor ligand family — synthetic peptides studied for their interaction with melanocortin receptors (MC1R–MC5R) in receptor-pharmacology research. This places it in a distinct receptor system from the growth-hormone-axis peptides elsewhere in this catalogue, such as the GHRH analogues (sermorelin, CJC-1295) and ghrelin-receptor ligands (ipamorelin).
PT-141 is supplied by PurePeptides strictly as a research material, with no claim regarding outcomes in humans or animals.
Purity and quality control in research-grade PT-141
In laboratory research, peptide purity has a direct bearing on reproducibility: synthesis by-products or residual reagents can confound experimental observations. PurePeptides supplies PT-141 at greater than 99% purity as a lyophilised powder.
In peptide manufacturing, purity is typically assessed by reverse-phase high-performance liquid chromatography (HPLC), while identity is confirmed by mass spectrometry (MS) against the expected molecular weight — approximately 1025.2 g/mol for PT-141. A certificate of analysis (COA) documenting these results is available on request for the current batch. When evaluating any research-grade peptide, requesting the COA and confirming both the purity figure and the mass-spec identity is good laboratory practice.
Frequently asked questions
PT-141 (Bremelanotide) is a synthetic cyclic heptapeptide and a ligand of the melanocortin receptor family, supplied as a lyophilised powder for research use only.
Bremelanotide has the molecular formula C50H68N14O10 and a molecular weight of approximately 1025.2 g/mol (CAS 189691-06-3).
It is also known as Bremelanotide.
In the research literature it is described as a ligand of the melanocortin receptor family, distinct from the GHRH- and ghrelin-receptor peptides studied elsewhere in this catalogue.
PurePeptides supplies PT-141 at greater than 99% purity as a lyophilised powder. A certificate of analysis (COA) is available on request for the current batch.
Store the lyophilised powder at -20°C, protected from light and moisture. In the laboratory it is commonly reconstituted with bacteriostatic water; once in solution, store refrigerated at 2-8°C and minimise freeze-thaw cycles.
Research-grade PT-141 is available from PurePeptides at greater than 99% purity, with same-day dispatch before 3PM and tracked UK & EU delivery. It is sold strictly for laboratory research use only.
Research-grade PT-141
Greater than 99% purity, lyophilised powder, same-day dispatch before 3PM with tracked UK & EU delivery. Research use only.
Buy PT-141 →Disclaimer: All products supplied by PurePeptides are strictly for laboratory research use only. They are not for human or animal consumption and are not medical products. This guide is informational and summarises publicly available research; it is not medical, clinical, or dosing advice.